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KMID : 0387720130240020121
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Korean Journal of Blood Transfusion
2013 Volume.24 No. 2 p.121 ~ p.127
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Transfusion Premedication: A Single Center Study
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Kim Bo-Ram
Choi Jae-Lim
Kim Ji-Eun
Woo Kwang-Sook
Kim Jung-Man
Han Jin-Yeong
Kim Kyeong-Hee
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Abstract
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Background: Acute transfusion reaction occurs during or within a few hours of transfusion with 0.5∼3% of blood transfusion. Febrile non-hemolytic transfusion reactions (FNHTRs) and allergic transfusion reactions (ATRs) are the most common transfusion reactions. Premedication with acetaminophen and diphenhydramine has been used to prevent these reactions in 50∼80% of transfusions. The purpose of this study was to describe the frequency of premedication and FNHTRs and ATRs according to premedication in Korea.
Methods: Between January 1 and 31, 2013, analysis of the first transfusion was performed retrospectively with chart review. A total of 549 cases were analyzed with regard to product of blood, care area, premedication, and FNHTRs and ATRs.
Results: Premedication was administered in 88.2% (484/549) of transfusions; 4 mg chlorphenamine, a well-known antihistamine, was used as premedication in all cases. Occurrence of FNHTRs was 7.7% without premedication and 3.7% with premedication. Occurrence of ATRs was 0% without premedication and 0.8% with premedication. The frequency of premedication was related to care area but not blood products.
Conclusion: Premedication use was more frequent than previously reported. However, the sample size in this study is small; therefore, conduct of further prospective multicenter studies is needed.
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KEYWORD
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Premedication, Transfusion reaction, Febrile non-hemolytic transfusion reaction, Allergic transfusion reaction
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